Detailed information of TA system TA148517

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20027..20365
• Replicon: chromosome
• Accession: NZ_CP047924
• Organism: Staphylococcus aureus strain SR130

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: GWG03_RS00110
• Protein ID: WP_072482930.1
• Coordinates: 20027..20203 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20191..20365 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWG03_RS00090	17856..18008	+	153	WP_001000058.1	hypothetical protein	-
GWG03_RS00095	18054..18341	+	288	WP_001262621.1	hypothetical protein	-
GWG03_RS00100	18397..18771	+	375	WP_000340977.1	hypothetical protein	-
GWG03_RS00105	19144..19917	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
GWG03_RS00110	20027..20203	+	177	WP_072482930.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20191..20365	-	175	-	-	Antitoxin
GWG03_RS00120	20415..20669	+	255	WP_000611512.1	phage holin	-
GWG03_RS00125	20681..21436	+	756	WP_000861040.1	CHAP domain-containing protein	-
GWG03_RS00130	21627..22118	+	492	WP_000920042.1	staphylokinase	-
GWG03_RS00135	22769..23103	+	335	Protein_26	SH3 domain-containing protein	-
GWG03_RS00140	23198..23647	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
GWG03_RS00145	24330..24680	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
GWG03_RS00150	24733..24993	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / chp / scn	1..24680	24679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T148517 WP_072482930.1 NZ_CP047924:20027-20203 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T148517 NZ_CP063768:3586421-3587167 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCAGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTAGTAGGCGCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCAGCTTATGGAGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT148517 NZ_CP047924:c20365-20191 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATATAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin