Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2737428..2737690 Replicon chromosome
Accession NZ_CP047922
Organism Staphylococcus aureus strain SR231

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag GWG04_RS13590 Protein ID WP_001802298.1
Coordinates 2737428..2737532 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2737527..2737690 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWG04_RS13570 2734225..2735007 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
GWG04_RS13575 2735075..2735932 + 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
GWG04_RS13580 2736590..2736748 - 159 WP_001792784.1 hypothetical protein -
GWG04_RS13585 2736741..2736911 - 171 WP_001792292.1 transposase -
GWG04_RS13590 2737428..2737532 + 105 WP_001802298.1 hypothetical protein Toxin
- 2737527..2737690 - 164 - - Antitoxin
GWG04_RS13595 2737965..2739056 - 1092 WP_000495669.1 hypothetical protein -
GWG04_RS13600 2739322..2740299 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
GWG04_RS13605 2740301..2740621 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
GWG04_RS13610 2740773..2741438 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T148511 WP_001802298.1 NZ_CP047922:2737428-2737532 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T148511 NZ_CP063761:36493-36651 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 164 bp

>AT148511 NZ_CP047922:c2737690-2737527 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References