Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2462704..2463221 | Replicon | chromosome |
| Accession | NZ_CP047922 | ||
| Organism | Staphylococcus aureus strain SR231 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | GWG04_RS12170 | Protein ID | WP_000113265.1 |
| Coordinates | 2462955..2463221 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | GWG04_RS12165 | Protein ID | WP_000584499.1 |
| Coordinates | 2462704..2462955 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GWG04_RS12135 (2458401) | 2458401..2459120 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| GWG04_RS12140 (2459117) | 2459117..2459848 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| GWG04_RS12145 (2459945) | 2459945..2461196 | - | 1252 | Protein_2374 | FemA/FemB family glycyltransferase FmhA | - |
| GWG04_RS12150 (2461451) | 2461451..2461813 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| GWG04_RS12155 (2461832) | 2461832..2462431 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| GWG04_RS12160 (2462459) | 2462459..2462539 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| GWG04_RS12165 (2462704) | 2462704..2462955 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GWG04_RS12170 (2462955) | 2462955..2463221 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| GWG04_RS12175 (2463256) | 2463256..2463327 | + | 72 | Protein_2380 | hypothetical protein | - |
| GWG04_RS12180 (2463516) | 2463516..2465063 | + | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| GWG04_RS12185 (2465249) | 2465249..2465716 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| GWG04_RS12190 (2465800) | 2465800..2465982 | + | 183 | WP_000230292.1 | hypothetical protein | - |
| GWG04_RS12195 (2466199) | 2466199..2467023 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| GWG04_RS12200 (2467257) | 2467257..2467793 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T148510 WP_000113265.1 NZ_CP047922:2462955-2463221 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T148510 NZ_CP063760:c144457-144014 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT148510 WP_000584499.1 NZ_CP047922:2462704-2462955 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT148510 NZ_CP063760:c144684-144454 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|