Detailed information of TA system TA148508

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2437664..2437848
• Replicon: chromosome
• Accession: NZ_CP047922
• Organism: Staphylococcus aureus strain SR231

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: GWG04_RS12035
• Protein ID: WP_000482652.1
• Coordinates: 2437664..2437771 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2437788..2437848 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWG04_RS12010	2433026..2433499	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
GWG04_RS12015	2433622..2434833	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
GWG04_RS12020	2435015..2435674	-	660	WP_000831298.1	membrane protein	-
GWG04_RS12025	2435734..2436876	-	1143	WP_001176863.1	glycerate kinase	-
GWG04_RS12030	2437144..2437530	+	387	WP_000779360.1	flippase GtxA	-
GWG04_RS12035	2437664..2437771	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2437788..2437848	-	61	-	-	Antitoxin
GWG04_RS12040	2438474..2440237	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
GWG04_RS12045	2440262..2441995	+	1734	WP_212563496.1	ABC transporter ATP-binding protein	-
GWG04_RS12050	2442262..2442393	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148508 WP_000482652.1 NZ_CP047922:2437664-2437771 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148508 NZ_CP063760:c60794-60483 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148508 NZ_CP047922:c2437848-2437788 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin