Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1074840..1075254 | Replicon | chromosome |
| Accession | NZ_CP047922 | ||
| Organism | Staphylococcus aureus strain SR231 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | GWG04_RS05370 | Protein ID | WP_103147883.1 |
| Coordinates | 1075003..1075254 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GWG04_RS05365 | Protein ID | WP_000028424.1 |
| Coordinates | 1074840..1075013 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GWG04_RS05320 (1069927) | 1069927..1072374 | - | 2448 | WP_103147886.1 | virulence-associated E family protein | - |
| GWG04_RS05325 (1072662) | 1072662..1072862 | - | 201 | WP_000265252.1 | DUF1514 family protein | - |
| GWG04_RS05330 (1072930) | 1072930..1073082 | - | 153 | WP_000595263.1 | transcriptional activator RinB | - |
| GWG04_RS05335 (1073079) | 1073079..1073468 | - | 390 | WP_001596346.1 | hypothetical protein | - |
| GWG04_RS05340 (1073458) | 1073458..1073694 | - | 237 | WP_000608275.1 | hypothetical protein | - |
| GWG04_RS05345 (1073687) | 1073687..1073890 | - | 204 | WP_000141180.1 | hypothetical protein | - |
| GWG04_RS05350 (1073887) | 1073887..1074093 | - | 207 | WP_103147885.1 | DUF1381 domain-containing protein | - |
| GWG04_RS05355 (1074130) | 1074130..1074663 | - | 534 | WP_103147884.1 | dUTP diphosphatase | - |
| GWG04_RS05360 (1074678) | 1074678..1074839 | - | 162 | WP_000889684.1 | hypothetical protein | - |
| GWG04_RS05365 (1074840) | 1074840..1075013 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| GWG04_RS05370 (1075003) | 1075003..1075254 | - | 252 | WP_103147883.1 | DUF1024 family protein | Toxin |
| GWG04_RS05375 (1075247) | 1075247..1075555 | - | 309 | WP_000144708.1 | hypothetical protein | - |
| GWG04_RS05380 (1075552) | 1075552..1075899 | - | 348 | WP_000979209.1 | YopX family protein | - |
| GWG04_RS05385 (1075896) | 1075896..1076297 | - | 402 | WP_103147882.1 | hypothetical protein | - |
| GWG04_RS05390 (1076300) | 1076300..1076506 | - | 207 | WP_021285869.1 | hypothetical protein | - |
| GWG04_RS05395 (1076521) | 1076521..1076769 | - | 249 | WP_103147881.1 | phi PVL orf 51-like protein | - |
| GWG04_RS05400 (1076769) | 1076769..1077023 | - | 255 | WP_000111487.1 | DUF3310 domain-containing protein | - |
| GWG04_RS05405 (1077023) | 1077023..1077424 | - | 402 | WP_000113974.1 | PVL family protein | - |
| GWG04_RS05410 (1077424) | 1077424..1077609 | - | 186 | WP_001164629.1 | DUF3113 family protein | - |
| GWG04_RS05415 (1077622) | 1077622..1079574 | - | 1953 | Protein_1041 | DNA polymerase | - |
| GWG04_RS05420 (1079642) | 1079642..1080199 | - | 558 | WP_000645048.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1042447..1087855 | 45408 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9463.40 Da Isoelectric Point: 3.7666
>T148505 WP_103147883.1 NZ_CP047922:c1075254-1075003 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIDLDEAVGIMVSQVVYKYEEEQE
NEY
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIDLDEAVGIMVSQVVYKYEEEQE
NEY
Download Length: 252 bp
>T148505 NZ_CP063759:c4999373-4999089 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT148505 WP_000028424.1 NZ_CP047922:c1075013-1074840 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT148505 NZ_CP063759:c4999605-4999363 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|