Detailed information of TA system TA148503

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 174435..174615
• Replicon: chromosome
• Accession: NZ_CP047922
• Organism: Staphylococcus aureus strain SR231

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: GWG04_RS01095
• Protein ID: WP_001801861.1
• Coordinates: 174520..174615 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	174435..174492 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWG04_RS01065	170143..170277	+	135	WP_001791797.1	hypothetical protein	-
GWG04_RS01070	170441..171997	+	1557	WP_212563504.1	type I restriction-modification system subunit M	-
GWG04_RS01075	171990..173220	+	1231	Protein_176	restriction endonuclease subunit S	-
GWG04_RS01080	173762..174172	+	411	WP_001808705.1	IS21 family transposase	-
GWG04_RS01085	174157..174318	+	162	Protein_178	transposase	-
GWG04_RS01090	174296..174397	-	102	WP_001792025.1	hypothetical protein	-
-	174435..174492	+	58	-	-	Antitoxin
GWG04_RS01095	174520..174615	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
GWG04_RS01100	174760..175772	+	1013	Protein_181	IS3 family transposase	-
GWG04_RS01105	175970..176542	-	573	WP_000414216.1	hypothetical protein	-
GWG04_RS01110	176643..176984	-	342	WP_000627540.1	DUF3969 family protein	-
GWG04_RS01115	177025..177651	-	627	WP_000669024.1	hypothetical protein	-
GWG04_RS01120	177726..178721	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
GWG04_RS01125	178802..179452	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	132288..179416	47128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T148503 WP_001801861.1 NZ_CP047922:c174615-174520 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T148503 NZ_CP063759:4281010-4281228 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT148503 NZ_CP047922:174435-174492 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin