Detailed information of TA system TA148496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 4072652..4073172
• Replicon: chromosome
• Accession: NZ_CP047898
• Organism: Pseudarthrobacter sp. YJ56

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GU243_RS19175
• Protein ID: WP_160677452.1
• Coordinates: 4072652..4072924 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GU243_RS19180
• Protein ID: WP_160677455.1
• Coordinates: 4072921..4073172 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GU243_RS19160	4068395..4068994	-	600	WP_160677446.1	recombination mediator RecR	-
GU243_RS19165	4069058..4072441	-	3384	WP_160677449.1	DNA polymerase III subunit gamma and tau	-
GU243_RS19175	4072652..4072924	-	273	WP_160677452.1	Txe/YoeB family addiction module toxin	Toxin
GU243_RS19180	4072921..4073172	-	252	WP_160677455.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GU243_RS19185	4073526..4073825	+	300	WP_160677458.1	hypothetical protein	-
GU243_RS19190	4073946..4074839	+	894	WP_160677461.1	GIY-YIG nuclease family protein	-
GU243_RS19195	4074859..4075134	-	276	WP_201762323.1	hypothetical protein	-
GU243_RS19200	4075299..4075625	-	327	WP_160677464.1	hypothetical protein	-
GU243_RS19210	4076129..4077046	-	918	WP_160677467.1	DUF2236 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10652.96 Da
• Isoelectric Point: 8.0568

>T148496 WP_160677452.1 NZ_CP047898:c4072924-4072652 [Pseudarthrobacter sp. YJ56]
MKLSWDESAWEDYLWWQAQDRRTMKRINALIQDIARNGNEGIGKPEPLKHGFHGYWSRRITDEHRLVYRYAEGGSGVEIL
IAACRYHYGN

Nucleotide

• Length: 273 bp

>T148496 NZ_CP063749:61065-61370 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9550.64 Da
• Isoelectric Point: 4.9108

>AT148496 WP_160677455.1 NZ_CP047898:c4073172-4072921 [Pseudarthrobacter sp. YJ56]
VKTLTYSQSRAHYKETLDAVTDDREEVIITRPGKEDVVMVSRADYESLRETAYLLRSPANARRILESIERLESGHGTERD
LLE

Nucleotide

• Length: 252 bp

>AT148496 NZ_CP063749:60845-61063 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA