148460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1818415..1818917 Replicon chromosome
Accession NZ_CP047876
Organism Escherichia coli strain LD22-1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GUU87_RS08630 Protein ID WP_001471733.1
Coordinates 1818663..1818917 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag GUU87_RS08625 Protein ID WP_001259255.1
Coordinates 1818415..1818666 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU87_RS08600 1813602..1814669 - 1068 WP_001374028.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
GUU87_RS08605 1814669..1815739 - 1071 WP_001374029.1 histidinol-phosphate transaminase -
GUU87_RS08610 1815736..1817040 - 1305 WP_001748534.1 histidinol dehydrogenase -
GUU87_RS08615 1817046..1817945 - 900 WP_001374031.1 ATP phosphoribosyltransferase -
GUU87_RS08620 1818091..1818132 - 42 WP_010989201.1 his operon leader peptide -
GUU87_RS08625 1818415..1818666 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
GUU87_RS08630 1818663..1818917 + 255 WP_001471733.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
GUU87_RS08635 1819000..1819824 + 825 WP_160183908.1 SDR family oxidoreductase -
GUU87_RS08640 1819870..1820799 + 930 WP_001374016.1 LysR family transcriptional regulator -
GUU87_RS08645 1821014..1821076 + 63 WP_010723108.1 membrane protein YoeI -
GUU87_RS08650 1821066..1822424 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T148460 WP_001471733.1 NZ_CP047876:1818663-1818917 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T148460 NZ_CP063659:2211049-2211387 [Synechocystis sp. PCC 7339]
ATGAATATTTGGGTTGATGCTCAATTACCCCCAACATTGGCAGATTGGCTGTCCAGTAGTTTTGATTTAGAGGCTGCGGC
TTTGAGAGATCTTGGATTACGGGATGCCAAAGACATTGAAATTTTTGATGCGGCACGAGTTGCCAACTCTGTAATCATGA
CAAAAGACAGCGATTTTGTTGATCTTGTCTGTCGGTTAGGAATACCACCTCAGATTATTTGGCTGACTTGTGGCAATGTT
ACGAATCGAAACTTACGTCGGATTCTTTCAAGTACCTTGCCAAAGGCTTTAGAAAAACTGCAAGAAGGCGAAATGATTGT
AGAAATCAGCAGCCCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT148460 WP_001259255.1 NZ_CP047876:1818415-1818666 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT148460 NZ_CP063659:2210828-2211052 [Synechocystis sp. PCC 7339]
ATGAATAGTCTACTGTCTCGTGTTACTCAAATCCCCGGTCAGTGTGGTGGTCGTCCTTGTATCCGAGGGATGAGGATTCG
AGTGAGCGACATTTTAGAAATGTTGGCTGAAAATGTTAGCACCTCTGAGATTTTAGAGGATTTTCCAGACCTAGAAATTG
CAGATATTCAGGCTTGTCTCGTCTTTGCTGCACGACGAACTGATTTTCCCCAGTTGACCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References