Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 1818415..1818917 | Replicon | chromosome |
Accession | NZ_CP047876 | ||
Organism | Escherichia coli strain LD22-1 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | - |
Locus tag | GUU87_RS08630 | Protein ID | WP_001471733.1 |
Coordinates | 1818663..1818917 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | GUU87_RS08625 | Protein ID | WP_001259255.1 |
Coordinates | 1818415..1818666 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GUU87_RS08600 | 1813602..1814669 | - | 1068 | WP_001374028.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
GUU87_RS08605 | 1814669..1815739 | - | 1071 | WP_001374029.1 | histidinol-phosphate transaminase | - |
GUU87_RS08610 | 1815736..1817040 | - | 1305 | WP_001748534.1 | histidinol dehydrogenase | - |
GUU87_RS08615 | 1817046..1817945 | - | 900 | WP_001374031.1 | ATP phosphoribosyltransferase | - |
GUU87_RS08620 | 1818091..1818132 | - | 42 | WP_010989201.1 | his operon leader peptide | - |
GUU87_RS08625 | 1818415..1818666 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
GUU87_RS08630 | 1818663..1818917 | + | 255 | WP_001471733.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
GUU87_RS08635 | 1819000..1819824 | + | 825 | WP_160183908.1 | SDR family oxidoreductase | - |
GUU87_RS08640 | 1819870..1820799 | + | 930 | WP_001374016.1 | LysR family transcriptional regulator | - |
GUU87_RS08645 | 1821014..1821076 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
GUU87_RS08650 | 1821066..1822424 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10195.64 Da Isoelectric Point: 8.0353
>T148460 WP_001471733.1 NZ_CP047876:1818663-1818917 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T148460 NZ_CP063659:2211049-2211387 [Synechocystis sp. PCC 7339]
ATGAATATTTGGGTTGATGCTCAATTACCCCCAACATTGGCAGATTGGCTGTCCAGTAGTTTTGATTTAGAGGCTGCGGC
TTTGAGAGATCTTGGATTACGGGATGCCAAAGACATTGAAATTTTTGATGCGGCACGAGTTGCCAACTCTGTAATCATGA
CAAAAGACAGCGATTTTGTTGATCTTGTCTGTCGGTTAGGAATACCACCTCAGATTATTTGGCTGACTTGTGGCAATGTT
ACGAATCGAAACTTACGTCGGATTCTTTCAAGTACCTTGCCAAAGGCTTTAGAAAAACTGCAAGAAGGCGAAATGATTGT
AGAAATCAGCAGCCCATAA
ATGAATATTTGGGTTGATGCTCAATTACCCCCAACATTGGCAGATTGGCTGTCCAGTAGTTTTGATTTAGAGGCTGCGGC
TTTGAGAGATCTTGGATTACGGGATGCCAAAGACATTGAAATTTTTGATGCGGCACGAGTTGCCAACTCTGTAATCATGA
CAAAAGACAGCGATTTTGTTGATCTTGTCTGTCGGTTAGGAATACCACCTCAGATTATTTGGCTGACTTGTGGCAATGTT
ACGAATCGAAACTTACGTCGGATTCTTTCAAGTACCTTGCCAAAGGCTTTAGAAAAACTGCAAGAAGGCGAAATGATTGT
AGAAATCAGCAGCCCATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT148460 WP_001259255.1 NZ_CP047876:1818415-1818666 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT148460 NZ_CP063659:2210828-2211052 [Synechocystis sp. PCC 7339]
ATGAATAGTCTACTGTCTCGTGTTACTCAAATCCCCGGTCAGTGTGGTGGTCGTCCTTGTATCCGAGGGATGAGGATTCG
AGTGAGCGACATTTTAGAAATGTTGGCTGAAAATGTTAGCACCTCTGAGATTTTAGAGGATTTTCCAGACCTAGAAATTG
CAGATATTCAGGCTTGTCTCGTCTTTGCTGCACGACGAACTGATTTTCCCCAGTTGACCGCATGA
ATGAATAGTCTACTGTCTCGTGTTACTCAAATCCCCGGTCAGTGTGGTGGTCGTCCTTGTATCCGAGGGATGAGGATTCG
AGTGAGCGACATTTTAGAAATGTTGGCTGAAAATGTTAGCACCTCTGAGATTTTAGAGGATTTTCCAGACCTAGAAATTG
CAGATATTCAGGCTTGTCTCGTCTTTGCTGCACGACGAACTGATTTTCCCCAGTTGACCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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