Detailed information of TA system TA148449

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2670033..2670311
• Replicon: chromosome
• Accession: NZ_CP047867
• Organism: Staphylococcus aureus strain UP_419

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S59_RS13135
• Protein ID: WP_001802298.1
• Coordinates: 2670033..2670137 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2670133..2670311 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S59_RS13120	2666830..2667612	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
E3S59_RS13125	2667680..2668537	+	858	WP_000370923.1	Cof-type HAD-IIB family hydrolase	-
E3S59_RS13130	2669195..2669353	-	159	WP_001792784.1	hypothetical protein	-
E3S59_RS13135	2670033..2670137	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2670133..2670311	-	179	-	-	Antitoxin
E3S59_RS13140	2670570..2671661	-	1092	WP_000495669.1	hypothetical protein	-
E3S59_RS13145	2671927..2672904	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
E3S59_RS13150	2672906..2673226	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S59_RS13155	2673378..2674043	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148449 WP_001802298.1 NZ_CP047867:2670033-2670137 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148449 NZ_CP063518:c3746323-3745916 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT148449 NZ_CP047867:c2670311-2670133 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin