Detailed information of TA system TA148445

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2380340..2380524
• Replicon: chromosome
• Accession: NZ_CP047867
• Organism: Staphylococcus aureus strain UP_419

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S59_RS11630
• Protein ID: WP_000482652.1
• Coordinates: 2380340..2380447 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2380464..2380524 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S59_RS11605	2375702..2376175	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
E3S59_RS11610	2376298..2377509	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S59_RS11615	2377691..2378350	-	660	WP_000831298.1	membrane protein	-
E3S59_RS11620	2378410..2379552	-	1143	WP_001176863.1	glycerate kinase	-
E3S59_RS11625	2379820..2380206	+	387	WP_000779360.1	flippase GtxA	-
E3S59_RS11630	2380340..2380447	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2380464..2380524	-	61	-	-	Antitoxin
E3S59_RS11635	2381150..2382913	+	1764	WP_160195536.1	ABC transporter ATP-binding protein/permease	-
E3S59_RS11640	2382938..2384671	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
E3S59_RS11645	2384902..2385069	+	168	Protein_2253	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148445 WP_000482652.1 NZ_CP047867:2380340-2380447 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148445 NZ_CP063518:c2802872-2802618 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148445 NZ_CP047867:c2380524-2380464 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin