Detailed information of TA system TA148431

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2717491..2717753
• Replicon: chromosome
• Accession: NZ_CP047865
• Organism: Staphylococcus aureus strain UP_844

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S61_RS13505
• Protein ID: WP_001802298.1
• Coordinates: 2717491..2717595 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2717590..2717753 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S61_RS13490	2714288..2715070	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
E3S61_RS13495	2715138..2715995	+	858	WP_000370923.1	Cof-type HAD-IIB family hydrolase	-
E3S61_RS13500	2716653..2716811	-	159	WP_001792784.1	hypothetical protein	-
E3S61_RS13505	2717491..2717595	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2717590..2717753	-	164	-	-	Antitoxin
E3S61_RS13510	2718028..2719119	-	1092	WP_000495669.1	hypothetical protein	-
E3S61_RS13515	2719385..2720362	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
E3S61_RS13520	2720364..2720684	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S61_RS13525	2720836..2721501	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148431 WP_001802298.1 NZ_CP047865:2717491-2717595 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148431 NZ_CP063517:48374-48532 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 164 bp

>AT148431 NZ_CP047865:c2717753-2717590 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin