Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2455985..2456502 Replicon chromosome
Accession NZ_CP047865
Organism Staphylococcus aureus strain UP_844

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag E3S61_RS12160 Protein ID WP_000113265.1
Coordinates 2456236..2456502 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S61_RS12155 Protein ID WP_000584499.1
Coordinates 2455985..2456236 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S61_RS12125 2451683..2452402 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3S61_RS12130 2452399..2453130 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S61_RS12135 2453227..2454477 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
E3S61_RS12140 2454732..2455094 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S61_RS12145 2455113..2455712 + 600 WP_000162810.1 DsbA family protein -
E3S61_RS12150 2455719..2455820 + 102 Protein_2352 hypothetical protein -
E3S61_RS12155 2455985..2456236 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S61_RS12160 2456236..2456502 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
E3S61_RS12165 2456537..2456608 + 72 Protein_2355 hypothetical protein -
E3S61_RS12170 2456797..2458344 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S61_RS12175 2458530..2458997 + 468 WP_000153347.1 SRPBCC domain-containing protein -
E3S61_RS12180 2459081..2459263 + 183 WP_000230292.1 hypothetical protein -
E3S61_RS12185 2459480..2460304 + 825 WP_000572038.1 formate/nitrite transporter family protein -
E3S61_RS12190 2460538..2461074 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T148430 WP_000113265.1 NZ_CP047865:2456236-2456502 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148430 NZ_CP063517:20669-20818 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148430 WP_000584499.1 NZ_CP047865:2455985-2456236 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148430 NZ_CP063517:c20624-20565 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References