Detailed information of TA system TA148428

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2430778..2430962
• Replicon: chromosome
• Accession: NZ_CP047865
• Organism: Staphylococcus aureus strain UP_844

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S61_RS12025
• Protein ID: WP_000482652.1
• Coordinates: 2430778..2430885 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2430902..2430962 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S61_RS12000	2426139..2426612	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
E3S61_RS12005	2426735..2427947	-	1213	Protein_2323	multidrug effflux MFS transporter	-
E3S61_RS12010	2428129..2428788	-	660	WP_000831298.1	membrane protein	-
E3S61_RS12015	2428848..2429990	-	1143	WP_001176863.1	glycerate kinase	-
E3S61_RS12020	2430258..2430644	+	387	WP_000779360.1	flippase GtxA	-
E3S61_RS12025	2430778..2430885	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2430902..2430962	-	61	-	-	Antitoxin
E3S61_RS12030	2431588..2433351	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
E3S61_RS12035	2433376..2435109	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
E3S61_RS12040	2435340..2435507	+	168	Protein_2330	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148428 WP_000482652.1 NZ_CP047865:2430778-2430885 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148428 NZ_CP063516:106989-107294 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148428 NZ_CP047865:c2430962-2430902 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin