Detailed information of TA system TA148411

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2379978..2380162
• Replicon: chromosome
• Accession: NZ_CP047863
• Organism: Staphylococcus aureus strain UP_1106

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S63_RS11690
• Protein ID: WP_000482652.1
• Coordinates: 2379978..2380085 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2380102..2380162 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S63_RS11665	2375340..2375813	+	474	WP_160199442.1	GyrI-like domain-containing protein	-
E3S63_RS11670	2375936..2377147	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S63_RS11675	2377329..2377988	-	660	WP_000831298.1	membrane protein	-
E3S63_RS11680	2378048..2379190	-	1143	WP_160199443.1	glycerate kinase	-
E3S63_RS11685	2379458..2379844	+	387	WP_000779360.1	flippase GtxA	-
E3S63_RS11690	2379978..2380085	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2380102..2380162	-	61	-	-	Antitoxin
E3S63_RS11695	2380788..2382551	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
E3S63_RS11700	2382576..2384309	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
E3S63_RS11705	2384540..2384707	+	168	Protein_2266	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148411 WP_000482652.1 NZ_CP047863:2379978-2380085 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148411 NZ_CP063515:c1943818-1943411 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148411 NZ_CP047863:c2380162-2380102 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin