Detailed information of TA system TA148397

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2700938..2701200
• Replicon: chromosome
• Accession: NZ_CP047861
• Organism: Staphylococcus aureus strain UP_1322

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S64_RS13415
• Protein ID: WP_001802298.1
• Coordinates: 2700938..2701042 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2701037..2701200 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S64_RS13395	2697735..2698517	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
E3S64_RS13400	2698585..2699442	+	858	WP_000370923.1	Cof-type HAD-IIB family hydrolase	-
E3S64_RS13405	2700100..2700258	-	159	WP_001792784.1	hypothetical protein	-
E3S64_RS13410	2700251..2700421	-	171	WP_001792292.1	transposase	-
E3S64_RS13415	2700938..2701042	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2701037..2701200	-	164	-	-	Antitoxin
E3S64_RS13420	2701475..2702566	-	1092	WP_000495669.1	hypothetical protein	-
E3S64_RS13425	2702832..2703809	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
E3S64_RS13430	2703811..2704131	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S64_RS13435	2704283..2704948	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148397 WP_001802298.1 NZ_CP047861:2700938-2701042 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148397 NZ_CP063511:2947441-2947695 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT148397 NZ_CP047861:c2701200-2701037 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin