Detailed information of TA system TA148394

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2414287..2414471
• Replicon: chromosome
• Accession: NZ_CP047861
• Organism: Staphylococcus aureus strain UP_1322

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S64_RS11920
• Protein ID: WP_000482652.1
• Coordinates: 2414287..2414394 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2414411..2414471 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S64_RS11895	2409649..2410122	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
E3S64_RS11900	2410245..2411456	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S64_RS11905	2411638..2412297	-	660	WP_000831298.1	membrane protein	-
E3S64_RS11910	2412357..2413499	-	1143	WP_001176863.1	glycerate kinase	-
E3S64_RS11915	2413767..2414153	+	387	WP_000779360.1	flippase GtxA	-
E3S64_RS11920	2414287..2414394	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2414411..2414471	-	61	-	-	Antitoxin
E3S64_RS11925	2415097..2416860	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
E3S64_RS11930	2416885..2418618	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
E3S64_RS11935	2418849..2419016	+	168	Protein_2313	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148394 WP_000482652.1 NZ_CP047861:2414287-2414394 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148394 NZ_CP063511:2125217-2125552 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT148394 NZ_CP047861:c2414471-2414411 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin