Detailed information of TA system TA148381

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2707606..2707884
• Replicon: chromosome
• Accession: NZ_CP047859
• Organism: Staphylococcus aureus strain UP_1405

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S65_RS13460
• Protein ID: WP_001802298.1
• Coordinates: 2707606..2707710 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2707706..2707884 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S65_RS13445	2704403..2705185	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
E3S65_RS13450	2705253..2706110	+	858	WP_160199261.1	Cof-type HAD-IIB family hydrolase	-
E3S65_RS13455	2706768..2706926	-	159	WP_001792784.1	hypothetical protein	-
E3S65_RS13460	2707606..2707710	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2707706..2707884	-	179	-	-	Antitoxin
E3S65_RS13465	2708143..2709234	-	1092	WP_000495669.1	hypothetical protein	-
E3S65_RS13470	2709500..2710477	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
E3S65_RS13475	2710479..2710799	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S65_RS13480	2710951..2711616	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148381 WP_001802298.1 NZ_CP047859:2707606-2707710 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148381 NZ_CP063506:c73871-73455 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT148381 NZ_CP047859:c2707884-2707706 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin