148380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2707606..2707868 Replicon chromosome
Accession NZ_CP047859
Organism Staphylococcus aureus strain UP_1405

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag E3S65_RS13460 Protein ID WP_001802298.1
Coordinates 2707606..2707710 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2707705..2707868 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S65_RS13445 2704403..2705185 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
E3S65_RS13450 2705253..2706110 + 858 WP_160199261.1 Cof-type HAD-IIB family hydrolase -
E3S65_RS13455 2706768..2706926 - 159 WP_001792784.1 hypothetical protein -
E3S65_RS13460 2707606..2707710 + 105 WP_001802298.1 hypothetical protein Toxin
- 2707705..2707868 - 164 - - Antitoxin
E3S65_RS13465 2708143..2709234 - 1092 WP_000495669.1 hypothetical protein -
E3S65_RS13470 2709500..2710477 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
E3S65_RS13475 2710479..2710799 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
E3S65_RS13480 2710951..2711616 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T148380 WP_001802298.1 NZ_CP047859:2707606-2707710 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T148380 NZ_CP047859:2707606-2707710 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT148380 NZ_CP047859:c2707868-2707705 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References