Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2444641..2445158 Replicon chromosome
Accession NZ_CP047859
Organism Staphylococcus aureus strain UP_1405

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag E3S65_RS12110 Protein ID WP_000113265.1
Coordinates 2444892..2445158 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S65_RS12105 Protein ID WP_000584499.1
Coordinates 2444641..2444892 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S65_RS12075 2440339..2441058 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3S65_RS12080 2441055..2441786 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S65_RS12085 2441883..2443133 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
E3S65_RS12090 2443388..2443750 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S65_RS12095 2443769..2444368 + 600 WP_000162810.1 DsbA family protein -
E3S65_RS12100 2444375..2444476 + 102 Protein_2345 hypothetical protein -
E3S65_RS12105 2444641..2444892 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S65_RS12110 2444892..2445158 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
E3S65_RS12115 2445193..2445264 + 72 Protein_2348 hypothetical protein -
E3S65_RS12120 2445453..2447000 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S65_RS12125 2447186..2447653 + 468 WP_000153347.1 SRPBCC domain-containing protein -
E3S65_RS12130 2447737..2447919 + 183 WP_000230292.1 hypothetical protein -
E3S65_RS12135 2448136..2448960 + 825 WP_000572038.1 formate/nitrite transporter family protein -
E3S65_RS12140 2449194..2449730 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T148379 WP_000113265.1 NZ_CP047859:2444892-2445158 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148379 NZ_CP063506:9680-9886 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCTTTGCAGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGAG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148379 WP_000584499.1 NZ_CP047859:2444641-2444892 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148379 NZ_CP063506:c9693-9632 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References