Detailed information of TA system TA148377

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2419434..2419618
• Replicon: chromosome
• Accession: NZ_CP047859
• Organism: Staphylococcus aureus strain UP_1405

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S65_RS11975
• Protein ID: WP_000482652.1
• Coordinates: 2419434..2419541 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2419558..2419618 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S65_RS11950	2414796..2415269	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
E3S65_RS11955	2415392..2416603	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S65_RS11960	2416785..2417444	-	660	WP_000831298.1	membrane protein	-
E3S65_RS11965	2417504..2418646	-	1143	WP_001176863.1	glycerate kinase	-
E3S65_RS11970	2418914..2419300	+	387	WP_000779360.1	flippase GtxA	-
E3S65_RS11975	2419434..2419541	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2419558..2419618	-	61	-	-	Antitoxin
E3S65_RS11980	2420244..2422007	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
E3S65_RS11985	2422032..2423765	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
E3S65_RS11990	2423996..2424163	+	168	Protein_2323	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148377 WP_000482652.1 NZ_CP047859:2419434-2419541 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148377 NZ_CP063503:c4759247-4759140 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148377 NZ_CP047859:c2419618-2419558 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin