Detailed information of TA system TA148372

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 507481..508060
• Replicon: chromosome
• Accession: NZ_CP047859
• Organism: Staphylococcus aureus strain UP_1405

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3S65_RS02740
• Protein ID: WP_001025401.1
• Coordinates: 507481..507726 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	507695..508060 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S65_RS02700	503373..503987	+	615	WP_160199223.1	ATPase	-
E3S65_RS02705	503984..504130	-	147	WP_072433242.1	hypothetical protein	-
E3S65_RS02710	504167..504349	-	183	WP_000705240.1	hypothetical protein	-
E3S65_RS02715	504446..505366	-	921	WP_000348133.1	3'-5' exoribonuclease	-
E3S65_RS02720	505382..505996	-	615	WP_000801423.1	XRE family transcriptional regulator	-
E3S65_RS02725	506168..506395	+	228	WP_001030311.1	hypothetical protein	-
E3S65_RS02730	506421..507197	+	777	WP_001148559.1	phage antirepressor	-
E3S65_RS02735	507213..507431	+	219	WP_001001383.1	hypothetical protein	-
E3S65_RS02740	507481..507726	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3S65_RS02745	507695..508060	-	366	WP_001128433.1	hypothetical protein	Antitoxin
E3S65_RS02750	508115..508330	+	216	WP_031867168.1	hypothetical protein	-
E3S65_RS02755	508357..508620	+	264	WP_001124192.1	helix-turn-helix domain-containing protein	-
E3S65_RS02760	508633..508794	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
E3S65_RS02765	508873..509196	+	324	WP_000174994.1	hypothetical protein	-
E3S65_RS02770	509211..509573	+	363	WP_031857745.1	hypothetical protein	-
E3S65_RS02775	509570..510736	+	1167	WP_031822698.1	DUF2800 domain-containing protein	-
E3S65_RS02780	510762..511319	+	558	WP_000645048.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T148372 WP_001025401.1 NZ_CP047859:507481-507726 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T148372 NZ_CP063503:c3959309-3958902 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT148372 NZ_CP047859:c508060-507695 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin