Detailed information of TA system TA148360

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2717044..2717306
• Replicon: chromosome
• Accession: NZ_CP047856
• Organism: Staphylococcus aureus strain UP_1435

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S66_RS13515
• Protein ID: WP_001802298.1
• Coordinates: 2717044..2717148 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2717143..2717306 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S66_RS13500	2713841..2714623	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
E3S66_RS13505	2714691..2715548	+	858	WP_000370923.1	Cof-type HAD-IIB family hydrolase	-
E3S66_RS13510	2716206..2716364	-	159	WP_001792784.1	hypothetical protein	-
E3S66_RS13515	2717044..2717148	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2717143..2717306	-	164	-	-	Antitoxin
E3S66_RS13520	2717581..2718672	-	1092	WP_000495669.1	hypothetical protein	-
E3S66_RS13525	2718938..2719915	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
E3S66_RS13530	2719917..2720237	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S66_RS13535	2720389..2721054	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148360 WP_001802298.1 NZ_CP047856:2717044-2717148 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148360 NZ_CP063503:1105245-1105643 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT148360 NZ_CP047856:c2717306-2717143 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin