Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2430580..2430764 Replicon chromosome
Accession NZ_CP047856
Organism Staphylococcus aureus strain UP_1435

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag E3S66_RS12030 Protein ID WP_000482652.1
Coordinates 2430580..2430687 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2430704..2430764 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S66_RS12005 2425942..2426415 + 474 WP_000456486.1 GyrI-like domain-containing protein -
E3S66_RS12010 2426538..2427749 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
E3S66_RS12015 2427931..2428590 - 660 WP_000831298.1 membrane protein -
E3S66_RS12020 2428650..2429792 - 1143 WP_001176863.1 glycerate kinase -
E3S66_RS12025 2430060..2430446 + 387 WP_000779360.1 flippase GtxA -
E3S66_RS12030 2430580..2430687 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2430704..2430764 - 61 - - Antitoxin
E3S66_RS12035 2431390..2433153 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
E3S66_RS12040 2433178..2434911 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
E3S66_RS12045 2435142..2435309 + 168 Protein_2331 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T148357 WP_000482652.1 NZ_CP047856:2430580-2430687 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T148357 NZ_CP063503:588661-588834 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 61 bp

>AT148357 NZ_CP047856:c2430764-2430704 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References