Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2710575..2710837 Replicon chromosome
Accession NZ_CP047854
Organism Staphylococcus aureus strain UP_1525

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag E3S68_RS13465 Protein ID WP_001802298.1
Coordinates 2710575..2710679 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2710674..2710837 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S68_RS13450 2707372..2708154 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
E3S68_RS13455 2708222..2709079 + 858 WP_000370923.1 Cof-type HAD-IIB family hydrolase -
E3S68_RS13460 2709737..2709895 - 159 WP_001792784.1 hypothetical protein -
E3S68_RS13465 2710575..2710679 + 105 WP_001802298.1 hypothetical protein Toxin
- 2710674..2710837 - 164 - - Antitoxin
E3S68_RS13470 2711112..2712203 - 1092 WP_000495669.1 hypothetical protein -
E3S68_RS13475 2712469..2713446 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
E3S68_RS13480 2713448..2713768 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
E3S68_RS13485 2713920..2714585 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T148342 WP_001802298.1 NZ_CP047854:2710575-2710679 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T148342 NZ_CP063499:1432720-1432827 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 164 bp

>AT148342 NZ_CP047854:c2710837-2710674 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References