Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2449126..2449643 Replicon chromosome
Accession NZ_CP047854
Organism Staphylococcus aureus strain UP_1525

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag E3S68_RS12120 Protein ID WP_000113265.1
Coordinates 2449377..2449643 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S68_RS12115 Protein ID WP_000584499.1
Coordinates 2449126..2449377 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S68_RS12085 2444824..2445543 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3S68_RS12090 2445540..2446271 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S68_RS12095 2446368..2447618 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
E3S68_RS12100 2447873..2448235 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S68_RS12105 2448254..2448853 + 600 WP_000162810.1 DsbA family protein -
E3S68_RS12110 2448860..2448961 + 102 Protein_2348 hypothetical protein -
E3S68_RS12115 2449126..2449377 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S68_RS12120 2449377..2449643 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
E3S68_RS12125 2449678..2449749 + 72 Protein_2351 hypothetical protein -
E3S68_RS12130 2449938..2451485 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S68_RS12135 2451671..2452138 + 468 WP_000153347.1 SRPBCC domain-containing protein -
E3S68_RS12140 2452222..2452404 + 183 WP_000230292.1 hypothetical protein -
E3S68_RS12145 2452621..2453445 + 825 WP_000572038.1 formate/nitrite transporter family protein -
E3S68_RS12150 2453679..2454215 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T148341 WP_000113265.1 NZ_CP047854:2449377-2449643 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148341 NZ_CP063499:c1287278-1286991 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148341 WP_000584499.1 NZ_CP047854:2449126-2449377 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148341 NZ_CP063499:c1287517-1287278 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References