Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2423919..2424103 Replicon chromosome
Accession NZ_CP047854
Organism Staphylococcus aureus strain UP_1525

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag E3S68_RS11985 Protein ID WP_000482652.1
Coordinates 2423919..2424026 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2424043..2424103 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S68_RS11960 2419281..2419754 + 474 WP_000456486.1 GyrI-like domain-containing protein -
E3S68_RS11965 2419877..2421088 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
E3S68_RS11970 2421270..2421929 - 660 WP_000831298.1 membrane protein -
E3S68_RS11975 2421989..2423131 - 1143 WP_001176863.1 glycerate kinase -
E3S68_RS11980 2423399..2423785 + 387 WP_000779360.1 flippase GtxA -
E3S68_RS11985 2423919..2424026 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2424043..2424103 - 61 - - Antitoxin
E3S68_RS11990 2424729..2426492 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
E3S68_RS11995 2426517..2428250 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
E3S68_RS12000 2428481..2428648 + 168 Protein_2326 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T148339 WP_000482652.1 NZ_CP047854:2423919-2424026 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T148339 NZ_CP063499:769937-770040 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT148339 NZ_CP047854:c2424103-2424043 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References