Detailed information of TA system TA148325

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2615288..2615566
• Replicon: chromosome
• Accession: NZ_CP047852
• Organism: Staphylococcus aureus strain UP_274

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S71_RS12895
• Protein ID: WP_001802298.1
• Coordinates: 2615288..2615392 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2615388..2615566 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S71_RS12880	2612085..2612867	+	783	WP_000908175.1	ABC transporter ATP-binding protein	-
E3S71_RS12885	2612935..2613792	+	858	WP_000370926.1	Cof-type HAD-IIB family hydrolase	-
E3S71_RS12890	2614450..2614608	-	159	WP_001792784.1	hypothetical protein	-
E3S71_RS12895	2615288..2615392	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2615388..2615566	-	179	-	-	Antitoxin
E3S71_RS12900	2615834..2616925	-	1092	WP_000495671.1	lytic regulatory protein	-
E3S71_RS12905	2617191..2618171	-	981	WP_000019745.1	CDF family zinc efflux transporter CzrB	-
E3S71_RS12910	2618173..2618493	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S71_RS12915	2618645..2619310	+	666	WP_001024093.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148325 WP_001802298.1 NZ_CP047852:2615288-2615392 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148325 NZ_CP063492:c5208954-5208640 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAATCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT148325 NZ_CP047852:c2615566-2615388 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin