Detailed information of TA system TA148321

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2328683..2328867
• Replicon: chromosome
• Accession: NZ_CP047852
• Organism: Staphylococcus aureus strain UP_274

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S71_RS11415
• Protein ID: WP_000482652.1
• Coordinates: 2328683..2328790 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2328807..2328867 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S71_RS11390	2324045..2324518	+	474	WP_000456484.1	GyrI-like domain-containing protein	-
E3S71_RS11395	2324641..2325852	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S71_RS11400	2326034..2326693	-	660	WP_000831298.1	membrane protein	-
E3S71_RS11405	2326753..2327895	-	1143	WP_001176863.1	glycerate kinase	-
E3S71_RS11410	2328163..2328549	+	387	WP_000779357.1	flippase GtxA	-
E3S71_RS11415	2328683..2328790	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2328807..2328867	-	61	-	-	Antitoxin
E3S71_RS11420	2329437..2331200	+	1764	WP_001064809.1	ABC transporter ATP-binding protein/permease	-
E3S71_RS11425	2331225..2332958	+	1734	WP_031918671.1	ABC transporter ATP-binding protein/permease	-
E3S71_RS11430	2333189..2333356	+	168	Protein_2199	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148321 WP_000482652.1 NZ_CP047852:2328683-2328790 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148321 NZ_CP063492:4960776-4961153 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148321 NZ_CP047852:c2328867-2328807 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin