Detailed information of TA system TA148317

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 187478..187658
• Replicon: chromosome
• Accession: NZ_CP047852
• Organism: Staphylococcus aureus strain UP_274

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S71_RS01145
• Protein ID: WP_001801861.1
• Coordinates: 187563..187658 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	187478..187535 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S71_RS01115	183186..183320	+	135	Protein_184	hypothetical protein	-
E3S71_RS01120	183485..185041	+	1557	WP_000028583.1	type I restriction-modification system subunit M	-
E3S71_RS01125	185034..186263	+	1230	WP_047230715.1	restriction endonuclease subunit S	-
E3S71_RS01130	186715..187209	+	495	Protein_187	transposase	-
E3S71_RS01135	187200..187361	+	162	Protein_188	transposase	-
E3S71_RS01140	187339..187440	-	102	WP_001792025.1	hypothetical protein	-
-	187478..187535	+	58	-	-	Antitoxin
E3S71_RS01145	187563..187658	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3S71_RS01150	187803..188815	+	1013	Protein_191	IS3 family transposase	-
E3S71_RS01155	189014..189586	-	573	WP_000414215.1	hypothetical protein	-
E3S71_RS01160	189687..190028	-	342	WP_000627537.1	DUF3969 family protein	-
E3S71_RS01165	190069..190695	-	627	WP_000669026.1	hypothetical protein	-
E3S71_RS01170	190770..191765	-	996	WP_000070641.1	DUF4352 domain-containing protein	-
E3S71_RS01175	191846..192496	-	651	WP_072470537.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	152089..193254	41165

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T148317 WP_001801861.1 NZ_CP047852:c187658-187563 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T148317 NZ_CP063492:c3170525-3170247 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT148317 NZ_CP047852:187478-187535 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin