Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2507908..2508092 Replicon chromosome
Accession NZ_CP047851
Organism Staphylococcus aureus strain UP_338

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag E3S74_RS12350 Protein ID WP_000482647.1
Coordinates 2507985..2508092 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2507908..2507968 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S74_RS12335 2503418..2503585 - 168 Protein_2389 hypothetical protein -
E3S74_RS12340 2503816..2505549 - 1734 WP_000486505.1 ABC transporter ATP-binding protein/permease -
E3S74_RS12345 2505574..2507337 - 1764 WP_001064829.1 ABC transporter ATP-binding protein/permease -
- 2507908..2507968 + 61 - - Antitoxin
E3S74_RS12350 2507985..2508092 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
E3S74_RS12355 2508226..2508612 - 387 WP_000779351.1 flippase GtxA -
E3S74_RS12360 2508880..2510022 + 1143 WP_001176855.1 glycerate kinase -
E3S74_RS12365 2510082..2510741 + 660 WP_000831298.1 membrane protein -
E3S74_RS12370 2510923..2512134 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
E3S74_RS12375 2512257..2512730 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T148311 WP_000482647.1 NZ_CP047851:c2508092-2507985 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T148311 NZ_CP063492:c1984646-1984428 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT148311 NZ_CP047851:2507908-2507968 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References