148310

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2482606..2483123 Replicon chromosome
Accession NZ_CP047851
Organism Staphylococcus aureus strain UP_338

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag E3S74_RS12215 Protein ID WP_000251928.1
Coordinates 2482606..2482872 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag E3S74_RS12220 Protein ID WP_000584497.1
Coordinates 2482872..2483123 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S74_RS12190 2477814..2478350 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
E3S74_RS12195 2478818..2479642 - 825 WP_000594640.1 formate/nitrite transporter family protein -
E3S74_RS12200 2479845..2480027 - 183 WP_000079140.1 hypothetical protein -
E3S74_RS12205 2480113..2480580 - 468 WP_000153340.1 SRPBCC domain-containing protein -
E3S74_RS12210 2480766..2482313 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S74_RS12215 2482606..2482872 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
E3S74_RS12220 2482872..2483123 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S74_RS12225 2483287..2483387 - 101 Protein_2367 hypothetical protein -
E3S74_RS12230 2483394..2483993 - 600 WP_000162804.1 DsbA family protein -
E3S74_RS12235 2484012..2484374 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S74_RS12240 2484629..2485879 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
E3S74_RS12245 2485976..2486707 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
E3S74_RS12250 2486704..2487423 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T148310 WP_000251928.1 NZ_CP047851:c2482872-2482606 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148310 NZ_CP063492:1755189-1755530 [Escherichia coli]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTACTTGC
TGCAATGCTGATTCTTGCTGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGATACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCGGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT148310 WP_000584497.1 NZ_CP047851:c2483123-2482872 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT148310 NZ_CP063492:1755540-1755839 [Escherichia coli]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGTGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACTCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCGAATGGTAAGAGAATTGCATTTCAGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References