Detailed information of TA system TA148309

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 2219451..2219648
• Replicon: chromosome
• Accession: NZ_CP047851
• Organism: Staphylococcus aureus strain UP_338

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: E3S74_RS10860
• Protein ID: WP_073392962.1
• Coordinates: 2219544..2219648 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2219451..2219489 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S74_RS10840	2214525..2214845	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S74_RS10845	2214847..2215827	+	981	WP_000019741.1	CDF family zinc efflux transporter CzrB	-
E3S74_RS10850	2216093..2217184	+	1092	WP_000495684.1	hypothetical protein	-
E3S74_RS10855	2217472..2219118	+	1647	WP_000277741.1	IS1182-like element ISSau3 family transposase	-
-	2219451..2219489	+	39	-	-	Antitoxin
E3S74_RS10860	2219544..2219648	-	105	WP_073392962.1	hypothetical protein	Toxin
E3S74_RS10865	2220328..2220486	+	159	WP_001792784.1	hypothetical protein	-
E3S74_RS10870	2221145..2222002	-	858	WP_000370937.1	Cof-type HAD-IIB family hydrolase	-
E3S74_RS10875	2222070..2222852	-	783	WP_000908186.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2217472..2219118	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3920.80 Da
• Isoelectric Point: 5.5724

>T148309 WP_073392962.1 NZ_CP047851:c2219648-2219544 [Staphylococcus aureus]
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148309 NZ_CP063492:c1455241-1455089 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT148309 NZ_CP047851:2219451-2219489 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin