Detailed information of TA system TA148303

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1926652..1926832
• Replicon: chromosome
• Accession: NZ_CP047851
• Organism: Staphylococcus aureus strain UP_338

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S74_RS09235
• Protein ID: WP_001801861.1
• Coordinates: 1926652..1926747 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1926775..1926832 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S74_RS09200	1921795..1922421	+	627	WP_000669038.1	hypothetical protein	-
E3S74_RS09205	1922462..1922806	+	345	WP_000627550.1	DUF3969 family protein	-
E3S74_RS09210	1922904..1923476	+	573	WP_000414222.1	hypothetical protein	-
E3S74_RS09215	1923625..1924566	-	942	WP_001794355.1	FRG domain-containing protein	-
E3S74_RS09220	1924583..1924993	-	411	WP_107375236.1	hypothetical protein	-
E3S74_RS09225	1924993..1925562	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
E3S74_RS09230	1925755..1926201	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
E3S74_RS09235	1926652..1926747	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1926775..1926832	-	58	-	-	Antitoxin
E3S74_RS09240	1926870..1926971	+	102	WP_001791232.1	hypothetical protein	-
E3S74_RS09245	1927146..1927589	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
E3S74_RS09250	1927589..1928032	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
E3S74_RS09255	1928032..1928474	-	443	Protein_1825	DUF1433 domain-containing protein	-
E3S74_RS09260	1928999..1931419	+	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / selk	1919236..1960169	40933
	-	flank	IS/Tn	-	-	1931449..1933095	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T148303 WP_001801861.1 NZ_CP047851:1926652-1926747 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T148303 NZ_CP063492:c347338-347153 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT148303 NZ_CP047851:c1926832-1926775 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin