Detailed information of TA system TA148299

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1590966..1591545
• Replicon: chromosome
• Accession: NZ_CP047851
• Organism: Staphylococcus aureus strain UP_338

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3S74_RS07580
• Protein ID: WP_001025401.1
• Coordinates: 1591300..1591545 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1590966..1591331 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S74_RS07540	1587709..1588266	-	558	WP_000645048.1	DUF2815 family protein	-
E3S74_RS07545	1588292..1589458	-	1167	WP_031834538.1	DUF2800 domain-containing protein	-
E3S74_RS07550	1589455..1589817	-	363	WP_000985976.1	hypothetical protein	-
E3S74_RS07555	1589832..1590155	-	324	WP_000174994.1	hypothetical protein	-
E3S74_RS07560	1590234..1590395	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
E3S74_RS07565	1590408..1590671	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
E3S74_RS07570	1590696..1590911	-	216	WP_001097552.1	hypothetical protein	-
E3S74_RS07575	1590966..1591331	+	366	WP_001128433.1	hypothetical protein	Antitoxin
E3S74_RS07580	1591300..1591545	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3S74_RS07585	1591574..1592350	-	777	WP_001148544.1	Rha family transcriptional regulator	-
E3S74_RS07590	1592364..1592600	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
E3S74_RS07595	1592752..1593066	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
E3S74_RS07600	1593079..1593540	+	462	WP_000525004.1	hypothetical protein	-
E3S74_RS07605	1593558..1594142	+	585	WP_000825948.1	hypothetical protein	-
E3S74_RS07610	1594481..1595104	-	624	WP_001166482.1	hypothetical protein	-
E3S74_RS07615	1595214..1596419	+	1206	WP_000264191.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1551826..1614069	62243

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T148299 WP_001025401.1 NZ_CP047851:c1591545-1591300 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T148299 NZ_CP063488:c134553-134173 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGCATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT148299 NZ_CP047851:1590966-1591331 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin