Detailed information of TA system TA148298

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1009052..1009301
• Replicon: chromosome
• Accession: NZ_CP047851
• Organism: Staphylococcus aureus strain UP_338

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: E3S74_RS04815
• Protein ID: WP_000623369.1
• Coordinates: 1009052..1009159 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1009154..1009301 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S74_RS04790	1005725..1006294	-	570	WP_000287265.1	competence protein ComK	-
E3S74_RS04795	1006504..1006722	+	219	WP_000876825.1	IDEAL domain-containing protein	-
E3S74_RS04800	1006803..1007789	-	987	WP_160200224.1	lipoate--protein ligase	-
E3S74_RS04805	1007988..1008164	+	177	WP_000214898.1	YkvS family protein	-
E3S74_RS04810	1008179..1008781	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
E3S74_RS04815	1009052..1009159	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	1009154..1009301	-	148	-	-	Antitoxin
E3S74_RS04820	1009698..1009799	+	102	WP_001790623.1	hypothetical protein	-
E3S74_RS04825	1009809..1010081	+	273	WP_001794574.1	lactococcin 972 family bacteriocin	-
E3S74_RS04830	1010125..1012089	+	1965	WP_000870819.1	bacteriocin-associated integral membrane family protein	-
E3S74_RS04835	1012092..1012412	+	321	WP_000873929.1	YxeA family protein	-
E3S74_RS04840	1012409..1013050	+	642	WP_000571191.1	ABC transporter ATP-binding protein	-
E3S74_RS04845	1013138..1013428	-	291	WP_001791476.1	hypothetical protein	-
E3S74_RS04850	1013769..1014056	+	288	WP_000410718.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T148298 WP_000623369.1 NZ_CP047851:1009052-1009159 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T148298 NZ_CP063488:c76302-76015 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGATTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT148298 NZ_CP047851:c1009301-1009154 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGATATGCAGGAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTTCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin