Detailed information of TA system TA148291

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2597720..2597983
• Replicon: chromosome
• Accession: NZ_CP047849
• Organism: Staphylococcus aureus strain UP_403

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S76_RS12770
• Protein ID: WP_001802298.1
• Coordinates: 2597720..2597824 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2597819..2597983 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S76_RS12745	2593104..2593886	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
E3S76_RS12750	2593954..2594811	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
E3S76_RS12755	2595516..2595608	-	93	WP_001790138.1	hypothetical protein	-
E3S76_RS12760	2595897..2597033	+	1137	WP_000115564.1	SAP domain-containing protein	-
E3S76_RS12765	2597076..2597559	+	484	Protein_2468	recombinase family protein	-
E3S76_RS12770	2597720..2597824	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2597819..2597983	-	165	-	-	Antitoxin
E3S76_RS12775	2598324..2599415	-	1092	WP_000495671.1	lytic regulatory protein	-
E3S76_RS12780	2599681..2600661	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
E3S76_RS12785	2600663..2600983	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S76_RS12790	2601135..2601800	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148291 WP_001802298.1 NZ_CP047849:2597720-2597824 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148291 NZ_CP063487:3593422-3593673 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATAGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT148291 NZ_CP047849:c2597983-2597819 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin