Detailed information of TA system TA148288

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2307357..2307541
• Replicon: chromosome
• Accession: NZ_CP047849
• Organism: Staphylococcus aureus strain UP_403

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: E3S76_RS11255
• Protein ID: WP_000482650.1
• Coordinates: 2307357..2307464 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2307481..2307541 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S76_RS11230	2302719..2303192	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
E3S76_RS11235	2303315..2304526	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S76_RS11240	2304708..2305367	-	660	WP_000831298.1	membrane protein	-
E3S76_RS11245	2305427..2306569	-	1143	WP_001176863.1	glycerate kinase	-
E3S76_RS11250	2306837..2307223	+	387	WP_000779358.1	flippase GtxA	-
E3S76_RS11255	2307357..2307464	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2307481..2307541	-	61	-	-	Antitoxin
E3S76_RS11260	2308092..2309855	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
E3S76_RS11265	2309880..2311613	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
E3S76_RS11270	2311844..2312011	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148288 WP_000482650.1 NZ_CP047849:2307357-2307464 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148288 NZ_CP063487:2562792-2563088 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148288 NZ_CP047849:c2307541-2307481 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin