Detailed information of TA system TA148280

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20157..20495
• Replicon: chromosome
• Accession: NZ_CP047849
• Organism: Staphylococcus aureus strain UP_403

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3S76_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20157..20333 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20321..20495 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S76_RS00085	17844..17996	+	153	WP_000654329.1	hypothetical protein	-
E3S76_RS00090	18043..18330	+	288	WP_001040255.1	hypothetical protein	-
E3S76_RS00095	18386..18760	+	375	WP_000340977.1	hypothetical protein	-
E3S76_RS00100	19181..19954	+	774	WP_025174055.1	staphylococcal enterotoxin type P	-
E3S76_RS00105	20157..20333	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	20321..20495	-	175	-	-	Antitoxin
E3S76_RS00115	20545..20799	+	255	WP_000611512.1	phage holin	-
E3S76_RS00120	20811..21566	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3S76_RS00125	21757..22248	+	492	WP_000920038.1	staphylokinase	-
E3S76_RS00130	22899..23234	+	336	Protein_26	SH3 domain-containing protein	-
E3S76_RS00135	23745..24095	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3S76_RS00140	24148..24408	-	261	WP_001791826.1	hypothetical protein	-
E3S76_RS00145	24719..24898	-	180	WP_000669791.1	hypothetical protein	-
E3S76_RS00150	25220..25470	-	251	Protein_30	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	blaZ	see / sak / scn / hlb / map	1..83686	83685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T148280 WP_011447039.1 NZ_CP047849:20157-20333 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T148280 NZ_CP047849:20157-20333 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT148280 NZ_CP047849:c20495-20321 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin