Detailed information of TA system TA148275

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2615136..2615414
• Replicon: chromosome
• Accession: NZ_CP047847
• Organism: Staphylococcus aureus strain UP_522

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S80_RS13080
• Protein ID: WP_001802298.1
• Coordinates: 2615136..2615240 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2615236..2615414 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S80_RS13065	2611933..2612715	+	783	WP_000908180.1	ABC transporter ATP-binding protein	-
E3S80_RS13070	2612783..2613640	+	858	WP_047928586.1	Cof-type HAD-IIB family hydrolase	-
E3S80_RS13075	2614298..2614456	-	159	WP_001792784.1	hypothetical protein	-
E3S80_RS13080	2615136..2615240	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2615236..2615414	-	179	-	-	Antitoxin
E3S80_RS13085	2615682..2616773	-	1092	WP_000495681.1	hypothetical protein	-
E3S80_RS13090	2617039..2618019	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
E3S80_RS13095	2618021..2618341	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S80_RS13100	2618493..2619158	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148275 WP_001802298.1 NZ_CP047847:2615136-2615240 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148275 NZ_CP063483:c4710731-4710444 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT148275 NZ_CP047847:c2615414-2615236 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin