Detailed information of TA system TA148271

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2336341..2336525
• Replicon: chromosome
• Accession: NZ_CP047847
• Organism: Staphylococcus aureus strain UP_522

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S80_RS11630
• Protein ID: WP_000482647.1
• Coordinates: 2336341..2336448 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2336465..2336525 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S80_RS11605	2331713..2332186	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
E3S80_RS11610	2332309..2333520	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S80_RS11615	2333702..2334361	-	660	WP_000831298.1	membrane protein	-
E3S80_RS11620	2334421..2335563	-	1143	WP_001176863.1	glycerate kinase	-
E3S80_RS11625	2335821..2336207	+	387	WP_000779360.1	flippase GtxA	-
E3S80_RS11630	2336341..2336448	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2336465..2336525	-	61	-	-	Antitoxin
E3S80_RS11635	2337076..2338839	+	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
E3S80_RS11640	2338864..2340597	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
E3S80_RS11645	2340828..2340995	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148271 WP_000482647.1 NZ_CP047847:2336341-2336448 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148271 NZ_CP063483:3388217-3388324 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148271 NZ_CP047847:c2336525-2336465 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin