Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2336341..2336525 Replicon chromosome
Accession NZ_CP047847
Organism Staphylococcus aureus strain UP_522

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag E3S80_RS11630 Protein ID WP_000482647.1
Coordinates 2336341..2336448 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2336465..2336525 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S80_RS11605 2331713..2332186 + 474 WP_000456489.1 GyrI-like domain-containing protein -
E3S80_RS11610 2332309..2333520 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
E3S80_RS11615 2333702..2334361 - 660 WP_000831298.1 membrane protein -
E3S80_RS11620 2334421..2335563 - 1143 WP_001176863.1 glycerate kinase -
E3S80_RS11625 2335821..2336207 + 387 WP_000779360.1 flippase GtxA -
E3S80_RS11630 2336341..2336448 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2336465..2336525 - 61 - - Antitoxin
E3S80_RS11635 2337076..2338839 + 1764 WP_001064816.1 ABC transporter ATP-binding protein/permease -
E3S80_RS11640 2338864..2340597 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
E3S80_RS11645 2340828..2340995 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T148271 WP_000482647.1 NZ_CP047847:2336341-2336448 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T148271 NZ_CP063483:3388217-3388324 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 61 bp

>AT148271 NZ_CP047847:c2336525-2336465 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References