Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2304397..2304920 Replicon chromosome
Accession NZ_CP047847
Organism Staphylococcus aureus strain UP_522

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag E3S80_RS11490 Protein ID WP_047928625.1
Coordinates 2304654..2304920 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag E3S80_RS11485 Protein ID WP_000587618.1
Coordinates 2304397..2304654 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S80_RS11465 2299462..2300655 + 1194 WP_000675407.1 MFS transporter -
E3S80_RS11470 2300893..2301642 - 750 WP_000072466.1 hypothetical protein -
E3S80_RS11475 2301837..2303414 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
E3S80_RS11480 2303582..2304037 - 456 WP_000732076.1 DUF1307 domain-containing protein -
E3S80_RS11485 2304397..2304654 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S80_RS11490 2304654..2304920 + 267 WP_047928625.1 Txe/YoeB family addiction module toxin Toxin
E3S80_RS11495 2305276..2306352 + 1077 WP_001076673.1 M42 family metallopeptidase -
E3S80_RS11500 2306600..2307262 + 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
E3S80_RS11505 2307255..2308031 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E3S80_RS11510 2308427..2309614 + 1188 WP_047928624.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10756.59 Da        Isoelectric Point: 10.3584

>T148270 WP_047928625.1 NZ_CP047847:2304654-2304920 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LWAWSHYD

Download         Length: 267 bp

>T148270 NZ_CP063483:3387682-3387789 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT148270 WP_000587618.1 NZ_CP047847:2304397-2304654 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148270 NZ_CP063483:c3387635-3387569 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References