Detailed information of TA system TA148260

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1594812..1594996
• Replicon: chromosome
• Accession: NZ_CP047845
• Organism: Staphylococcus aureus strain UP_591

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S82_RS08040
• Protein ID: WP_000482647.1
• Coordinates: 1594889..1594996 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1594812..1594872 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S82_RS08020	1590398..1590565	-	168	WP_031785511.1	hypothetical protein	-
E3S82_RS08025	1590796..1592529	-	1734	WP_160176601.1	ABC transporter ATP-binding protein/permease	-
E3S82_RS08030	1592578..1594317	-	1740	WP_001064831.1	ABC transporter ATP-binding protein/permease	-
E3S82_RS08035	1594695..1594862	-	168	WP_000301894.1	hypothetical protein	-
-	1594812..1594872	+	61	-	-	Antitoxin
E3S82_RS08040	1594889..1594996	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3S82_RS08045	1595130..1595516	-	387	WP_000779354.1	flippase GtxA	-
E3S82_RS08050	1595784..1596926	+	1143	WP_001176860.1	glycerate kinase	-
E3S82_RS08055	1596986..1597645	+	660	WP_000831298.1	membrane protein	-
E3S82_RS08060	1597825..1599036	+	1212	WP_001191975.1	multidrug effflux MFS transporter	-
E3S82_RS08065	1599159..1599632	-	474	WP_000456491.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148260 WP_000482647.1 NZ_CP047845:c1594996-1594889 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148260 NZ_CP063483:1442268-1442564 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148260 NZ_CP047845:1594812-1594872 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin