Detailed information of TA system TA148249

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2466008..2466192
• Replicon: chromosome
• Accession: NZ_CP047843
• Organism: Staphylococcus aureus strain UP_620

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S83_RS12335
• Protein ID: WP_000482647.1
• Coordinates: 2466085..2466192 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2466008..2466068 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S83_RS12320	2461462..2461629	-	168	WP_001792506.1	hypothetical protein	-
E3S83_RS12325	2461860..2463593	-	1734	WP_000486496.1	ABC transporter ATP-binding protein/permease	-
E3S83_RS12330	2463618..2465381	-	1764	WP_001064836.1	ABC transporter ATP-binding protein/permease	-
-	2466008..2466068	+	61	-	-	Antitoxin
E3S83_RS12335	2466085..2466192	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3S83_RS12340	2466326..2466712	-	387	WP_000779360.1	flippase GtxA	-
E3S83_RS12345	2466970..2468112	+	1143	WP_001176863.1	glycerate kinase	-
E3S83_RS12350	2468172..2468831	+	660	WP_000831295.1	hypothetical protein	-
E3S83_RS12355	2469013..2470224	+	1212	WP_061642252.1	multidrug effflux MFS transporter	-
E3S83_RS12360	2470347..2470820	-	474	WP_000456492.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148249 WP_000482647.1 NZ_CP047843:c2466192-2466085 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148249 NZ_CP063479:c4355280-4354945 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT148249 NZ_CP047843:2466008-2466068 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin