148248

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2440699..2441216 Replicon chromosome
Accession NZ_CP047843
Organism Staphylococcus aureus strain UP_620

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3S83_RS12200 Protein ID WP_000113262.1
Coordinates 2440699..2440965 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S83_RS12205 Protein ID WP_000584499.1
Coordinates 2440965..2441216 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S83_RS12175 2436122..2436658 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E3S83_RS12180 2436892..2437716 - 825 WP_000572040.1 formate/nitrite transporter family protein -
E3S83_RS12185 2437933..2438115 - 183 WP_000079142.1 hypothetical protein -
E3S83_RS12190 2438202..2438669 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E3S83_RS12195 2438855..2440405 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S83_RS12200 2440699..2440965 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3S83_RS12205 2440965..2441216 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S83_RS12210 2441381..2441482 - 102 Protein_2351 hypothetical protein -
E3S83_RS12215 2441489..2442088 - 600 WP_000162810.1 DsbA family protein -
E3S83_RS12220 2442107..2442469 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S83_RS12225 2442724..2443974 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E3S83_RS12230 2444071..2444802 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S83_RS12235 2444799..2445518 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T148248 WP_000113262.1 NZ_CP047843:c2440965-2440699 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148248 NZ_CP063479:c4023221-4022823 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148248 WP_000584499.1 NZ_CP047843:c2441216-2440965 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148248 NZ_CP063479:c4023448-4023221 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References