Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-sprA1AS/-
Location 2186107..2186304 Replicon chromosome
Accession NZ_CP047843
Organism Staphylococcus aureus strain UP_620

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag E3S83_RS10880 Protein ID WP_001802298.1
Coordinates 2186200..2186304 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2186107..2186145 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S83_RS10865 2181380..2182360 + 981 WP_000019739.1 CDF family zinc efflux transporter CzrB -
E3S83_RS10870 2182626..2183717 + 1092 WP_000495672.1 hypothetical protein -
E3S83_RS10875 2183746..2185392 - 1647 WP_000277718.1 IS1182 family transposase -
- 2186107..2186145 + 39 - - Antitoxin
E3S83_RS10880 2186200..2186304 - 105 WP_001802298.1 hypothetical protein Toxin
E3S83_RS10885 2186984..2187142 + 159 WP_001792784.1 hypothetical protein -
E3S83_RS10890 2187801..2188658 - 858 WP_000370931.1 Cof-type HAD-IIB family hydrolase -
E3S83_RS10895 2188726..2189508 - 783 WP_000908174.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2183746..2185392 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T148247 WP_001802298.1 NZ_CP047843:c2186304-2186200 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T148247 NZ_CP063479:c3548108-3547857 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCATAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 39 bp

>AT148247 NZ_CP047843:2186107-2186145 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References