Detailed information of TA system TA148246

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2186042..2186304
• Replicon: chromosome
• Accession: NZ_CP047843
• Organism: Staphylococcus aureus strain UP_620

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S83_RS10880
• Protein ID: WP_001802298.1
• Coordinates: 2186200..2186304 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2186042..2186205 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S83_RS10860	2181058..2181378	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S83_RS10865	2181380..2182360	+	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
E3S83_RS10870	2182626..2183717	+	1092	WP_000495672.1	hypothetical protein	-
E3S83_RS10875	2183746..2185392	-	1647	WP_000277718.1	IS1182 family transposase	-
-	2186042..2186205	+	164	-	-	Antitoxin
E3S83_RS10880	2186200..2186304	-	105	WP_001802298.1	hypothetical protein	Toxin
E3S83_RS10885	2186984..2187142	+	159	WP_001792784.1	hypothetical protein	-
E3S83_RS10890	2187801..2188658	-	858	WP_000370931.1	Cof-type HAD-IIB family hydrolase	-
E3S83_RS10895	2188726..2189508	-	783	WP_000908174.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2183746..2185392	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148246 WP_001802298.1 NZ_CP047843:c2186304-2186200 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148246 NZ_CP063479:c3547860-3547606 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT148246 NZ_CP047843:2186042-2186205 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin