Detailed information of TA system TA148236

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2572382..2572644
• Replicon: chromosome
• Accession: NZ_CP047841
• Organism: Staphylococcus aureus strain UP_644

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S84_RS12740
• Protein ID: WP_001802298.1
• Coordinates: 2572382..2572486 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2572481..2572644 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S84_RS12725	2569179..2569961	+	783	WP_000908180.1	ABC transporter ATP-binding protein	-
E3S84_RS12730	2570029..2570886	+	858	WP_047928586.1	Cof-type HAD-IIB family hydrolase	-
E3S84_RS12735	2571544..2571702	-	159	WP_001792784.1	hypothetical protein	-
E3S84_RS12740	2572382..2572486	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2572481..2572644	-	164	-	-	Antitoxin
E3S84_RS12745	2572928..2574019	-	1092	WP_000495681.1	hypothetical protein	-
E3S84_RS12750	2574285..2575265	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
E3S84_RS12755	2575267..2575587	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S84_RS12760	2575739..2576404	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148236 WP_001802298.1 NZ_CP047841:2572382-2572486 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148236 NZ_CP063479:c1190273-1189896 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT148236 NZ_CP047841:c2572644-2572481 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin