Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2318580..2319097 Replicon chromosome
Accession NZ_CP047841
Organism Staphylococcus aureus strain UP_644

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3S84_RS11430 Protein ID WP_000113262.1
Coordinates 2318831..2319097 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S84_RS11425 Protein ID WP_000584499.1
Coordinates 2318580..2318831 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S84_RS11395 2314278..2314997 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3S84_RS11400 2314994..2315725 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S84_RS11405 2315822..2317072 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
E3S84_RS11410 2317327..2317689 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S84_RS11415 2317708..2318307 + 600 WP_160176464.1 DsbA family protein -
E3S84_RS11420 2318314..2318415 + 102 WP_031774922.1 hypothetical protein -
E3S84_RS11425 2318580..2318831 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S84_RS11430 2318831..2319097 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3S84_RS11435 2319393..2320940 + 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S84_RS11440 2321126..2321593 + 468 WP_000153344.1 SRPBCC domain-containing protein -
E3S84_RS11445 2321677..2321859 + 183 WP_000230294.1 hypothetical protein -
E3S84_RS11450 2322076..2322900 + 825 WP_000572040.1 formate/nitrite transporter family protein -
E3S84_RS11455 2323133..2323669 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T148235 WP_000113262.1 NZ_CP047841:2318831-2319097 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148235 NZ_CP063479:1108983-1109333 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148235 WP_000584499.1 NZ_CP047841:2318580-2318831 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148235 NZ_CP063479:1108738-1108989 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References