Detailed information of TA system TA148233

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2293680..2293864
• Replicon: chromosome
• Accession: NZ_CP047841
• Organism: Staphylococcus aureus strain UP_644

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S84_RS11295
• Protein ID: WP_000482647.1
• Coordinates: 2293680..2293787 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2293804..2293864 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S84_RS11270	2289052..2289525	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
E3S84_RS11275	2289648..2290859	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S84_RS11280	2291041..2291700	-	660	WP_000831298.1	membrane protein	-
E3S84_RS11285	2291760..2292902	-	1143	WP_001176863.1	glycerate kinase	-
E3S84_RS11290	2293160..2293546	+	387	WP_000779360.1	flippase GtxA	-
E3S84_RS11295	2293680..2293787	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2293804..2293864	-	61	-	-	Antitoxin
E3S84_RS11300	2294415..2296178	+	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
E3S84_RS11305	2296203..2297936	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
E3S84_RS11310	2298167..2298334	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148233 WP_000482647.1 NZ_CP047841:2293680-2293787 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148233 NZ_CP063479:721405-721716 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148233 NZ_CP047841:c2293864-2293804 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin