Detailed information of TA system TA148232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2261736..2262259
• Replicon: chromosome
• Accession: NZ_CP047841
• Organism: Staphylococcus aureus strain UP_644

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E3S84_RS11155
• Protein ID: WP_047928625.1
• Coordinates: 2261993..2262259 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: E3S84_RS11150
• Protein ID: WP_000587618.1
• Coordinates: 2261736..2261993 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S84_RS11130	2256808..2258001	+	1194	WP_000675407.1	MFS transporter	-
E3S84_RS11135	2258232..2258981	-	750	WP_000072466.1	hypothetical protein	-
E3S84_RS11140	2259176..2260753	+	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
E3S84_RS11145	2260921..2261376	-	456	WP_000732076.1	DUF1307 domain-containing protein	-
E3S84_RS11150	2261736..2261993	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E3S84_RS11155	2261993..2262259	+	267	WP_047928625.1	Txe/YoeB family addiction module toxin	Toxin
E3S84_RS11160	2262615..2263691	+	1077	WP_001076673.1	M42 family metallopeptidase	-
E3S84_RS11165	2263939..2264601	+	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
E3S84_RS11170	2264594..2265370	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
E3S84_RS11175	2265766..2266953	+	1188	WP_047928624.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10756.59 Da
• Isoelectric Point: 10.3584

>T148232 WP_047928625.1 NZ_CP047841:2261993-2262259 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LWAWSHYD

Nucleotide

• Length: 267 bp

>T148232 NZ_CP063479:464656-465033 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT148232 WP_000587618.1 NZ_CP047841:2261736-2261993 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT148232 NZ_CP063479:464232-464609 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2